Tales Santini, Ph.D.

I'm interested in everything related to 7T MRI.

    Education & Training

  • BS in Electrical Engineering, University of Sao Paulo, Brazil
  • MSc in Electrical Engineering, Universivity of Sao Paulo, Brazil
  • PhD in Bioengineering, University of Pittsburgh, USA
Recent Publications
  1. Ariel G Gildengers, Tamer S Ibrahim, Xuemei Zeng, Howard J Aizenstein, Salem K Alkhateeb, Stewart J Anderson, Cong Chu, Jihui L Diaz, James E Emanuel, Thomas K Karikari, Jinghang Li, Oscar L Lopez, Brian J Lopresti, Sarah K Royse, Andrea N Sajewski, Tales Santini, Andrea M Weinstein, Minjie Wu, Meryl A Butters The LATTICE Study: Design of a pilot feasibility randomized controlled trial of lithium to delay cognitive decline in mild cognitive impairment Alzheimer's & Dementia: Translational Research & Clinical Interventions 2025
  2. Andrea N Sajewski, Tales Santini, Anthony DeFranco, Jacob Berardinelli, Hecheng Jin, Jinghang Li, Cong Chu, Jeremy J Berardo, Tamer S Ibrahim. RF shimming strategy for an open 60‐channel RF transmit 7T MRI head coil for routine use on the single transmit mode. Magnetic Resonance in Medicine 2025
  3. Jr-Jiun Liou, Jinghang Li, Jacob Berardinelli, Hecheng Jin, Tales Santini, Jaehoon Noh, Nadim Farhat, Minjie Wu, Howard J Aizenstein, Joseph M Mettenburg, William H Yong, Elizabeth Head, Milos D Ikonomovic, Tamer S Ibrahim, Julia K Kofler Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer’s disease and related neurodegenerative pathologies using 7T postmortem MRI. Journal of Neuropathology & Experimental Neurology 2025
  4. Tales Santini*, Cong Chu*, Jr‐Jiun Liou, Ann D Cohen, Pauline M Maki, Anna L Marsland, Rebecca C Thurston, Peter J Gianaros, Tamer S Ibrahim Brain Morphometrics Correlations With Age Among 350 Participants Imaged With Both 3T and 7T MRI: 7T Improves Statistical Power and Reduces Required Sample Size. Human Brain Mapping 2025. *equal contribuition
  5. Jr-Jiun Liou, Jerry Lou, Lisi Flores-Aguilar, Jamie Nakagiri, William Yong, Christy L Hom, Eric W Doran, Minodora O Totoiu, Ira Lott, Mark Mapstone, David B Keator, Adam M Brickman, Sierra T Wright, Brittany Nelson, Florence Lai, Laura Xicota, Lam-Ha T Dang, Jinghang Li, Tales Santini, Joseph M Mettenburg, Milos D Ikonomovic, Julia Kofler, Tamer Ibrahim, Elizabeth Head A neuropathology case report of a woman with Down syndrome who remained cognitively stable: Implications for resilience to neuropathology Alzheimer's & dementia 2025
  6. Kelsey L Canada, Negar Mazloum‐Farzaghi, Gustaf Rådman, Jenna N Adams, Arnold Bakker, Hannah Baumeister, David Berron, Martina Bocchetta, Valerie A Carr, Marshall A Dalton, Robin de Flores, Attila Keresztes, Renaud La Joie, Susanne G Mueller, Naftali Raz, Tales Santini, Thomas Shaw, Craig EL Stark, Tammy T Tran, Lei Wang, Laura EM Wisse, Anika Wuestefeld, Paul A Yushkevich, Rosanna K Olsen, Ana M Daugherty, Hippocampal Subfields Group A (sub)field guide to quality control in hippocampal subfield segmentation on high‐resolution T2‐weighted MRI Human brain mapping 2024
  7. Tales Santini, Alyson Shim, Jr‐Jiun Liou, Naila Rahman, Gabriel Varela‐Mattatall, Matthew D Budde, Wataru Inoue, Stefan Everling, Corey A Baron. Investigating microstructural changes between in vivo and perfused ex vivo marmoset brains using oscillating gradient and b-tensor encoded diffusion MRI at 9.4 T Magnetic Resonance in Medicine, 2025
  8. Lucy Liang, David J Schaeffer, Tales Santini, Isabela Zimmermann Rollin, Elvira Pirondini. Quality assessment for images obtained using 3D printed stereotaxic frame . Protocols 2024
  9. Lucy Liang, Isabela Zimmermann Rollin, Aydin Alikaya, Jonathan C Ho, Tales Santini, Andreea C Bostan, Helen N Schwerdt, William R Stauffer, Tamer S Ibrahim, Elvira Pirondini, David J Schaeffer. An open-source MRI compatible frame for multimodal presurgical mapping in macaque and capuchin monkeys . Journal of Neuroscience Methods, 2024
  10. Tiago Martins, Bruno De Almeida, Minjie Wu, Kristine A Wilckens, Davneet Minhas, James W Ibinson, Howard J Aizenstein, Tales Santini*, Tamer S Ibrahim*. Characterization of pulsations in the brain and cerebrospinal fluid using ultra-high field magnetic resonance imaging . Front. Neurosci., 2024. *co-corresponding authors
  11. Tales Santini, Chenyi Chen, Wen Zhu, Jr-Jiun Liou, Elizabeth Walker, Shruthi Venkatesh, Nadim Farhat, Andrea Sajewski, Salem Alkhateeb, Manojkumar Saranathan, Zongqi Xia, Tamer S. Ibrahim Hippocampal subfields and thalamic nuclei associations with clinical outcomes in multiple sclerosis: an ultrahigh field MRI study. Multiple Sclerosis and Related Disorders, 2024
  12. Brandon M. Sibbach, Helmet T. Karim, Daniel Lo, Nithya Kasibhatla, Tales Santini, Jessica C. Weber, Tamer S. Ibrahim, Layla Banihashemi Manual segmentation of the paraventricular nucleus of the hypothalamus and the dorsal and ventral bed nucleus of stria terminalis using multimodal 7 Tesla structural MRI: probabilistic atlases for a stress-control triad. Brain Structure and Function, 2023
  13. Tales Santini*, Bridget N McGuigan*, Matcheri S Keshavan, Konasale M Prasad. Gene expressions preferentially influence cortical thickness of Human Connectome Project Atlas parcellated regions in first-episode antipsychotic-naïve psychoses. Schizophrenia Bulletin Open, 2023. *equal contribuition
  14. S. Aja-Fernández, C. Martín-Martín, A. Planchuelo-Gómez, A. Faiyaz, M.N. Uddin, G. Schifitto, A. Tiwari, S.J. Shigwan, R. Kumar Singh, T. Zheng, Z. Cao, D. Wu, S.B. Blumberg, S. Sen, T. Goodwin-Allcock, P.J. Slator, M. Yigit Avci, Z. Li, B. Bilgic, Q. Tian, X. Wang, Z. Tang, M. Cabezas, A. Rauland, D. Merhof, R. Manzano Maria, V.P. Campos, T. Santini, M.A. da Costa Vieira, S. HashemizadehKolowri, E. DiBella, C. Peng, Z. Shen, Z. Chen, I. Ullah, M. Mani, H. Abdolmotalleby, S. Eckstrom, S.H. Baete, P. Filipiak, T. Dong, Q. Fan, R. de Luis-García, A. Tristán-Vega, T. Pieciak. Validation of Deep Learning techniques for quality augmentation in diffusion MRI for clinical studies. NeuroImage: Clinical, 2023
  15. Madison Lewis, Tales Santini, Nicholas Theis, Brendan Muldoon, Katherine Dash, Matcheri Keshavan, Konasale Prasad. Modular architecture and resilience of structural covariance networks in first-episode antipsychotic-naive psychoses. Scientific Reports. 2023
  16. Gabriel Varela-Mattatall, Paul I. Dubovan, Tales Santini, Kyle M. Gilbert, Ravi S. Menon, Corey A. Baron High-resolution single-shot spiral diffusion-weighted imaging at 7T using expanded encoding with compressed sensing. MRM 2023
  17. Nico J. J. Arezza, Tales Santini, Mohammad Omer, Corey A. Baron. Estimation of free water-corrected microscopic fractional anisotropy. Front. Neurosci. 2023
  18. Nicola De Zanche et al. ISMRM Best Practices for Safety Testing of Experimental RF Hardware, 2022.
  19. Mark Whiting, Joseph Mettenburg, Enrico Novelli, Tales Santini, Tiago Martins, Tamer S. Ibrahim, Philip LeDuc, Jonathan Cagan. Inducing Vascular Grammars for Anomaly Classification in Brain Angiograms. Journal of Engineering and Science in Medical Diagnostics and Therapy, 2022.
  20. Tales Santini*, Ashika Mani*, Radhika Puppala*, Megan Dahl, Shruthi Venkatesh, Elizabeth Walker, Megan DeHaven, Cigdem Isitan, Tamer S. Ibrahim, Long Wang, Tao Zhang, Enhao Gong, Jessica Barrios-Martinez, Fang-Cheng Yeh, Robert Krafty, Joseph M. Mettenburg, Zongqi Xia. Applying Deep Learning to Accelerated Clinical Brain Magnetic Resonance Imaging for Multiple Sclerosis. Front. Neurol., 2021. *Equal contribution.
  21. Tales Santini, Sossena Wood, Narayanan Krishnamurthy, Tiago Martins, Howard J. Aizenstein, Tamer S. Ibrahim. Improved 7 Tesla Transmit Field Homogeneity with Reduced Electromagnetic Power Deposition Using Coupled Tic Tac Toe Antennas. Scientific Reports, 2021.
  22. Tales Santini, Minseok Koo, Nadim Farhat, Vinicius P. Campos, Salem Alkhateeb, Marcelo A. C. Vieira, Meryl A. Butters, Caterina Rosano, Howard J. Aizenstein, Joseph Mettenburg, Enrico M. Novelli, Tamer S. Ibrahim. Analysis of Hippocampal Subfields in Sickle Cell Disease Using Ultrahigh Field MRI. Neuroimage: Clinical 2021.
  23. Sossena Wood, Tales Santini, Narayanan Krishnamurthy, Tiago Martins, Nadim Farhat, Tamer S. Ibrahim. A Comprehensive Electromagnetic Evaluation of an MRI Anthropomorphic Head Phantom. NMR in Biomedicine 2020.
  24. Nadim S. Farhat, Robert Theiss, Tales Santini, Tamer S. Ibrahim, Howard J. Aizenstein. Recent advances in Neuroimaging of Small Vessel Disease in Late-life Depression. Advances in Experimental Medicine and Biology (AEMB), book series of Springer, 2019.
  25. Stephen F. Smagula, Sarah T. Stahl, Tales Santini, Layla Banihashemi, Martica H. Hall, Tamer S. Ibrahim, Charles F. Reynolds III, Robert T. Krafty, Howard J. Aizenstein, Liang Zhan. White matter integrity underlying depression symptoms in dementia caregivers. American Journal of Geriatric Psychiatry, 2019.
  26. Tales Santini*, Narayanan Krishnamurthy*, Junghwan Kim, Sossena Wood, Howard Aizenstein, and Tamer S. Ibrahim. Computational and Experimental Evaluations of transmission line Based RF Coils at 7T. PLoS One 2019. *Equal contribution.
  27. Melania Borges, Marcelo Prado, Tales Santini, Adriano Barbosa, Antonio Moreira, Issao Ishibe, Marcelo Katz, Fatima Cintra. Development and clinical validation of a non-invasive, beat-to-beat blood pressure monitoring device, compared to invasive blood pressure monitoring during coronary angiography. Einstein Journal 2019.
  28. Tales Santini, Yujuan Zhao, Sossena Wood, Narayanan Krishnamurthy, Junghwan Kim, Nadim Farhat, Tiago Martins, Tiejun Zhao, Howard Aizenstein, and Tamer S. Ibrahim. In-vivo and numerical analysis of the eigenmodes produced by a multi-level head transmit array for 7 Tesla MRI. PLoS One 2018.
  29. Tales Santini, Junghwan Kim, Sossena Wood, Narayanan Krishnamurthy, Nadim Farhat, Carlos Maciel, Shailesh Raval, and Tamer Ibrahim. A new RF Transmit Coil for Foot and Ankle Imaging at 7T MRI. Magnetic Resonance Imaging 2018.
  30. Stephen F. Smagula, Helmet T. Karim, Anusha Rangarajan, Fernando Pasquini Santos, Sossena C. Wood, Tales Santini, John M. Jakicic, Charles F. Reynolds, Judy L. Cameron, Abbe N. Vallejo, Meryl A. Butters, Caterina Rosano, Tamer S. Ibrahim, Kirk I Erickson, and Howard J. Aizenstein. Association of hippocampal substructure resting-state functional connectivity with memory performance in older adults. American Journal of Geriatric Psychiatry 2018.
  31. Junghwan Kim, Tales Santini, Kyongtae Ty Bae, Narayan Krishnamurthy, Yujuan Zhao, Tiejun Zhao, and Tamer S. Ibrahim. Development of a 7 T RF coil system for breast imaging. NMR in Biomedicine 2017.
  32. Sossena Wood, Narayanan Krishnamurthy, Tales Santini, Shailesh Raval, Nadim Farhat, John Andy Holmes, and Tamer S. Ibrahim. Design and fabrication of a realistic anthropomorphic heterogeneous head phantom for MR purposes. PLoS One 2017.
  33. Shailesh B. Raval, Cynthia A. Britton, Tiejun Zhao, Narayanan Krishnamurthy, Tales Santini, Vijay S. Gorantla, Tamer S. Ibrahim. Ultra-high field upper extremity peripheral nerve and non-contrast enhanced vascular imaging. PLoS One 2017.
  34. Tales Santini, Tamer Ibrahim, and Carlos Maciel. Load-insensitive active quasi-circulator for continuous-wave Doppler ultrasound applications. Electronics Letters 2016.
  35. Junghwan Kim, Narayan Krishnamurthy, Tales Santini, Yujuan Zhao, Tiejun Zhao, Kyongtae Ty Bae, and Tamer S. Ibrahim. Experimental and numerical analysis of B1+ field and SAR with a new transmit array design for 7T breast MRI. Journal of Magnetic Resonance 2016.
  36. Shailesh B. Raval, Tiejun Zhao, Narayanan Krishnamurthy, Tales Santini, Cynthia Britton, Vijay S. Gorantla, Tamer S. Ibrahim. Ultra-high-field RF coil development for evaluating upper extremity imaging applications. NMR Biomed 2016
  37. Miguel Filho, Alexandre R. Marra, Thyago Magnus, Rodrigo Rodrigues, Marcelo Prado, Tales Santini, Elivane Victor, Eder Ishibe, Oscar Santos, Michael Edmond. Comparison of human and electronic observation for the measurement of compliance with hand hygiene. American Journal of Infection Control 2014.
Research Interests
  • RF coils
  • Diffusion/microstructural MRI
  • Morphometrics
  • Image processing
Tales Santini, Ph.D.
Contact Tales Santini, Ph.D.

1033B Biomedical Science Tower 3 (BST3)

https://www.tsantini.com